Task 1

Training/Validation: Download pairs_val.csv

Test: Download | pairs_val.csv

DescriptionThe database contains 22 subjects with low-grade brain gliomas and is intend to help develop MRI vs. US registration algorithms to correct tissue shift in brain tumor resection. For the task, we included the T1w and T2-FLAIR MRIs, and spatially tracked intra-operative ultrasound volumes taken after craniotomy and before resection started. Matching anatomical landmarks were annotated between T2FLAIR MRI and 3D ultrasound volumes to help validate registration algorithm accuracy. All scans were acquired for routine clinical care of brain tumor resection procedures at St Olavs University Hospital (Trondheim, Norway). For each clinical case, the pre-operative 3T MRI includes Gadolinium-enhanced T1w and T2 FLAIR scans, and the intra-operative US volume was obtained to cover the entire tumor region after craniotomy but before dura opening, as well as after resection was completed. A detailed user manual is included in the data package download.

Number of cases: Training: 22, Test: 10

Annotations: Matching anatomical landmarks were annotated between T2FLAIR MRI and 3D ultrasound volumes. The reference anatomical landmarks were selected by Rater 1 in the ultrasound volume before dura is open after craniotomy. Then two raters selected matching anatomical landmarks in the ultrasound volumes obtained after tumor resection using the software 'register' from MINC Toolkit. The ultrasound landmark selection was repeated twice for each rater with a time interval of at least one week. Finally, the results (4 points for each landmark location) were averaged. Eligible anatomical landmarks include deep grooves and corners of sulci, convex points of gyri, and vanishing points of sulci. Same raters produced the anatomical landmarks for both the training and testing data. To help with deep learning purposes, the landmarks have also been voxelized as spheres in the same 3D space as the MRI/US scans. In addition, the image header transforms are also provided separately for the users.

Pre-Processing: All MRI scans were corrected for field inhomogeneity, and T1w MRI is rigidly registered to T2FLAIR MRI. For each subject, the MRI and 3D ultrasound volumes were resampled to the same space and dimension (256x256x288) at an isotropic ~0.5mm resolution.

Non-disclosure Agreement: Unlike the training data, which were publicly released as the EASY-RESECT database, the CuRIOUS 2020 for Learn2Reg Challenge test data are not public. They cannot be shared and used for any purpose but the challenge evaluation.

Citation:  Y. Xiao, M. Fortin, G. Unsgård , H. Rivaz, and I. Reinertsen, “REtroSpective Evaluation of Cerebral Tumors (RESECT): a clinical database of pre-operative MRI and intra-operative ultrasound in low-grade glioma surgeries”. Medical Physics, Vol. 44(7), pp. 3875-3882, 2017. 

Task 2

Training/Validation: Download | pairs_val.csv

Test: Download | pairs_val.csv

Description: The database consists of 60 3D HRCT thorax images taken from 30 subjects. For each subject an inspiration and expiration scan is taken. The data was gathered from the Department of Radiology at the Radboud University Medical Center, Nijmegen, The Netherlands. One additional challenge with this data is that the lungs are not fully visible in the expiration scans. 

Number of cases: Training: 20, Test: 10

Annotation: For all scans an automatic lung segmentation is provided. For evaluating the registration methods, we use manually annotated landmarks. We also plan to provide automatically computed keypoint correspondences for all training pairs (these are considered noisy labels with residual errors of 1-2mm).

Pre-processing: Common pre-processing to same voxel resolutions and spatial dimensions as well as affine pre-registration will be provided to ease the use of learning-based algorithms for participants with little prior experience in image registration.

Citation: Hering, Alessa, Murphy,Keelin, and van Ginneken, Bram. (2020). Lean2Reg Challenge: CT Lung Registration - Training Data [Data set]. Zenodo. http://doi.org/10.5281/zenodo.3835682

Task 3

Training/Validation: Download | pairs_val.csv

Test: Download | pairs_val.csv

Description: All scans were captured during portal venous contrast phase with variable volume sizes (512 × 512 × 53 ~ 512 × 512 × 368) and field of views (approx. 280 × 280 × 225 mm3 ~ 500 × 500 × 760 mm3). The in-plane resolution varies from 0.54 × 0.54 mm2 to 0.98 × 0.98 mm2, while the slice thickness ranged from 1.5 mm to 7.0 mm.

Number of cases: Training: 30, Test: 20

Annotation: Thirteen abdominal organs were considered regions of interest (ROI), including spleen, right kidney, left kidney, gall bladder, esophagus, liver, stomach, aorta, inferior vena cava, portal and splenic vein, pancreas, left adrenal gland, and right adrenal gland. The organ selection was essentially based on [Shimizu A, Ohno R, Ikegami T, Kobatake H, Nawano S, Smutek D. Segmentation of multiple organs in non-contrast 3D abdominal CT images. International Journal of Computer Assisted Radiology and Surgery. 2007;2:135–142.]. As suggested by a radiologist, the heart was excluded for lack of full appearance in the datasets, and instead the adrenal glands were included for clinical interest. These ROIs were manually labeled by two experienced undergraduate students with 6 months of training on anatomy identification and labeling, and then verified by a radiologist on a volumetric basis using the MIPAV software.

Pre-processing: Common pre-processing to same voxel resolutions and spatial dimensions as well as affine pre-registration will be provided to ease the use of learning-based algorithms for participants with little prior experience in image registration.

Task 4

Training/Validation: Download | pairs_val.csv

Test: Download | pairs_val.csv

Description: The dataset consisted of MRI acquired in 90 healthy adults and 105 adults with a non-affective psychotic disorder (56 schizophrenia, 32 schizoaffective disorder, and 17 schizophreniform disorder) taken from the Psychiatric Genotype/Phenotype Project data repository at Vanderbilt University Medical Center (Nashville, TN, USA). Patients were recruited from the Vanderbilt Psychotic Disorders Program and controls were recruited from the surrounding community. The MRI data will show parts of the brain covering the hippocampus formation. The algorithm targets the alignment of two neighboring small structures (hippocampus head and body) with high precision on mono-modal MRI images between different patients (new insights into learning based registration due to a large-scale dataset). All images were collected on a Philips Achieva scanner (Philips Healthcare, Inc., Best, The Netherlands). Structural images were acquired with a 3D T1-weighted MPRAGE sequence (TI/TR/TE, 860/8.0/3.7 ms; 170 sagittal slices; voxel size, 1.0 mm3). The data is provided by the Vanderbilt University Medical Center (VUMC) and part of the medical segmentation decathlon. 

Number of cases: Training: 263, Test: 131

Annotation: We use anatomical segmentations (and deformation field statistics) to evaluate the registration. Manual tracing of the head, body, and tail of the hippocampus on images was completed following a previously published protocol [Pruessner, J. et al. Volumetry of hippocampus and amygdala with high- resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cerebral cortex 10, 433–442 (2000).; Woolard, A. & Heckers, S. Anatomical and functional correlates of human hippocampal volume asymmetry. Psychiatry Research: Neuroimaging 201, 48–53 (2012).]. For the purposes of this dataset, the term hippocampus includes the hippocampus proper (CA1-4 and dentate gyrus) and parts of the subiculum, which together are more often termed the hippocampal formation [Amaral, D. & Witter, M. The three-dimensional organization of the hip- pocampal formation: a review of anatomical data. Neuroscience 31, 571– 591 (1989)]. The last slice of the head of the hippocampus was defined as the coronal slice containing the uncal apex.

Pre-Processing: Common pre-processing to same voxel resolutions and spatial dimensions  will be provided to ease the use of learning-based algorithms for participants with little prior experience in image registration.

Citation: A Simpson et al.: "A large annotated medical image dataset for the development and evaluation of segmentation algorithms" arXiv 2019